Pyridone derivatives as acid secretion inhibitors and process for preparation thereof

The invention relates to pyridone derivatives as acid secretion inhibitors and a process for preparation thereof. Provided are pyridine disulphide derivatives of Formula (I) and their preparation, pharmaceutical composition. The pyridine disulphide derivatives are useful in the treatment of gastrointestinal disorders. wherein, R1, R2 and R3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be same or different and X is CH or N. R1 is methyl, methoxy, fluorine, trifluoromefhyl, difluoromethoxy and hydrogen, R2 is methyl, methoxy and hydrogen, and R3 is methyl and hydrogen. 本发明涉及作为酸分泌抑制剂的吡啶酮衍生物及其制备方法。特别地，本发明提供了式(I)的吡啶二硫化物衍生物和其制备、药物组合物。所述吡啶二硫化物衍生物用于治疗胃肠疾病。其中，R、R和R，可以相同或不同，且独立地为烷基、烷氧基、卤素、卤代烷氧基、卤代烷基、氢原子，并且X为CH或N。R为甲基、甲氧基、氟、三氟甲基、二氟甲氧基和氢原子，R为甲基、甲氧基和氢原子，且R为甲基和氢原子。