Oral insulin micelle nanoparticles and preparation method thereof

The invention discloses oral insulin micelle nanoparticles and a preparation method thereof. The preparation method comprises the following steps: dissolving an amphiphilic block copolymer with pH (Potential of Hydrogen) sensitivity, i.e., [poly(methyl methacrylate-co-methacrylate)-b-monomethoxypolyethylene glycol polymethacrylate P(MMA-co-MAA)-b-PPEGMA], into an organic solvent; dissolving insulin into a diluted acid solution with the concentration of 0.0001mol/L; then slowly dropwise adding an insulin solution into a polymer solution; sufficiently stirring; then transferring a mixed solutioninto a dialysis bag and dialyzing for 24 to 48h in the environment with the pH (Potential of Hydrogen) of 4.5 to 6.0; removing an organic solvent to form a polymer drug-loading micelle; centrifuging,freeing and drying to obtain the oral insulin micelle nanoparticles which have relatively uniform sizes, are micro-spherical and have the remarkable pH sensitivity and the quality entrapment rate of85 percent or above. 本发明公开种