Cephem compounds, their production and use

Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6- membered heteroaryl group (substituted or unsubstituted) whichis further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6- membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain. 头孢烯化合物、其药学上可接受的盐及其使用方法，其中所述化合物具有双环含氮芳杂环作为3位的季铵甲基，和以下中的个或两个：连接到芳基或5-或6-元杂芳基(取代的或未取代的)的末端脒残基(取代的或未取代的)，所述芳基或5-或6-元杂芳基(取代的或未取代的)还通过间隔基团连接到3-侧链上的含季氮的双环的游离N原子；或连接到芳基或5-或6-元杂芳基(取代的或未取代的)的末端胍残基，所述芳基或5-或6-元杂芳基(取代的或未取代的)还通过间隔基团连接到3-侧链上的含季氮的双环的游离N