Novel synthesis method of cefprozil

The invention belongs to the technical field of medicine synthesis and preparation and in particular relates to patent application of a novel cefprozil synthesis and preparation method. The method hasthe technical thought as follows: alkali substitution reaction is carried out on beta-lactam parent nucleus(7-amin-3-(Z-prop-1-enyl)-4-cephalosporanic acid) in an aprotic solvent; then a branched-chain D-p-hydroxyphenylglycine derivative is added to carry out condensation reaction, so that cefprozil is prepared. Totally, the preparation method provided by the invention has the advantages of easiness for obtaining reaction raw materials, moderate reaction conditions and easiness for controlling; after the reaction is finished, the residue of main raw materials is relatively low, the cost pressure caused by the main raw materials can be greatly reduced and the yield of the cefprozil is relatively high; meanwhile, the method has a relatively simple process route and a high-quality cefprozilproduct can be obtained th