Preparation method of 2,6-deoxy naphthol glycoside derivative

The invention discloses a preparation method of 2,6-deoxy naphthol glycoside derivative, characterized in that 1,3-bis-O-acetyl-4-O-benzyl-alpha-D-2,6-2-deoxyglucose or 1,3,4-tris-O-acetyl-alpha-D-2,6-2-deoxyglucose, as a donor, and 1,5-dihydroxynaphthalene, as a receptor, are dissolved in an organic solvent, the solution is subjected to c-glycosidation, and the resultant is subjected to acetylation to obtain naphthalene c-glycoside derivative containing a sugar ring, which is an intermediate to synthesize Marangucycline B. Compared with the prior art, the preparation method has a short reaction path with the yield increasable by 45%; agents are low in price and easy to obtain; the production cost is low; the problems are well solved that, for instance, c-glycoside synthetic yield is low,and reacting operations are complex; the use of high-toxicity chemical reagents is effectively avoided; the preparation method is green, environmentally friendly, economical and efficient for the preparation of synthetic inte