ANGIOGENESIS INHIBITOR

Provided is an angiogenesis inhibitor effective in the prevention of angiogenesis that becomes the cause of disease, the angiogenesis inhibitor is produced by, for instance, performing sterile filtration, disinfection, and concentration of a product in which biological decoration was carried out in a water-soluble polysaccharide extract, by: adding a water-soluble polysaccharide extract which is obtained by extracting bran with hot water, filtering the insoluble matter, and treating the filtrate with glucoamylase to decompose the starch, and an enzyme compound obtained from the precipitate resulting from adding ammonium sulfate to a culture filtrate obtained by culture of the basidiomycetes Lentinula edodes; and reacting the foregoing mixture for 30 to 60 minutes at a pH of 4.5, and then further reacting the foregoing mixture for 30 to 60 minutes at a pH of 6.0. 通过例如无菌过滤，消毒和浓缩如下获得的产物获得有效抑制导致疾病的血管生成的血管生成抑制剂，即：将米糠用热水提取，过滤不溶物，通过用葡糖淀粉酶处理滤液来分解淀粉，由此得到水溶性多糖提取物；将硫酸铵加入通过培养担子菌纲香菇(Lentinula edodes)制备的培养滤液中，由此从沉淀物中获得酶复合物