Method for preparing SteE (13-hydroxy ent-kaur-16-en-19-oic acid-beta-D-glucopyranosyl ester, steviol mono-glucosyl ester) and SteE crystal with crystal form A

The invention discloses a method for preparing SteE (13-hydroxy ent-kaur-16-en-19-oic acid-beta-D-glucopyranosyl ester, steviol mono-glucosyl ester) and a SteE crystal with a crystal form A, and belongs to the technical field of pharmaceutical chemistry. According to the method, firstly, stevioside...

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Bibliographische Detailangaben
Hauptverfasser:	PENG QINGRUI, XIA YONGMEI, FANG YUN, LIU XIANG, ZHANG TONGTONG, LI LEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPIRITS SUGARS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a method for preparing SteE (13-hydroxy ent-kaur-16-en-19-oic acid-beta-D-glucopyranosyl ester, steviol mono-glucosyl ester) and a SteE crystal with a crystal form A, and belongs to the technical field of pharmaceutical chemistry. According to the method, firstly, stevioside is catalyzed by pectinase, SteE is generated, after crude SteE products are collected, the SteE crystal with the crystal form A is prepared with a repeated crystallization method, not only can high-purity SteE be obtained in a SteE preparation process, but also the target crystal form can be obtained stably; a reagent used in the method is low-toxicity and environmentally friendly, and the method has the advantages that the technology is simple, operability and degree of crystallinity are high,stability is good and the like. 本发明公开了种制备甜菊醇单葡萄糖酯及其晶型A形式晶体的方法，属于药物化学技术领域。本发明先经果胶酶催化斯替夫苷生成甜菊醇单葡萄糖酯，收集甜菊醇单葡萄糖酯粗品后，采用了重复结晶的方法制备具有晶型A形式的甜菊醇单葡萄糖酯晶体，既可以在制备甜菊醇单葡萄糖酯的过程中获取高纯度的甜菊醇单葡萄糖酯又可以稳定地获得目标晶型，该方法所选试剂低毒环保，具有工艺简单、可操作性强，晶体结晶度高、稳定性好等