Process for preparing (S)-1-ferrocene ethyl dimethylamine

The invention discloses a process for preparing (S)-1-ferrocene ethyl dimethylamine. In the preparation process, acetylferrocene is used as a raw material, and a complex obtained by reacting a metal Ir complex with a chiral ferrocene tridentate ligand L* is used as a catalyst, (S)-1-ferrocenyl ethanol is prepared by asymmetric catalytic hydrogenation, and the(S)-1-ferrocene ethyl dimethylamine isprepared by acetylation and dimethylamine substitution reaction. Compared with a traditional chiral separation method for preparing the (S)-1-ferrocene ethyl dimethylamine, the process has main beneficial effects of mild reaction conditions, simple operation, good stereoselectivity, high yield, short production cycle, small amount of "three wastes", easy industrialization, and large implementationvalue and social and economic benefits. 本发明公开了种(S)-1-二茂铁乙基二甲胺的制备工艺。该制备工艺中，以乙酰基二茂铁作为原料，利用金属Ir络合物与手性二茂铁三齿配体L反应得到的配合物作为催化剂，经不对称催化氢化制得(S)-1-二茂铁基乙醇，然后进行乙酰化、二甲胺取代反应，得到(S)-1-二茂铁乙基二甲胺。与传统的手性拆分法制备(S)-1-二茂铁乙基二甲胺的工艺相比，本发明有益效果主要体现在：反应条件温