Method for preparing alpha-aryl nitrile compound

The invention discloses a method for preparing an alpha-aryl nitrile compound, and the method comprises reaction of aryl sulfoxide represented by the formula (I) and an alpha-tin-substituted nitrile compound represented by the formula (II) in a solvent to synthesize the alpha-aryl nitrile compound r...

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Hauptverfasser: LI KAIXIAO, YAO YONGNA, LI XINYAN, KANG TING, ZHAO WEIZHAO, YAN CHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for preparing an alpha-aryl nitrile compound, and the method comprises reaction of aryl sulfoxide represented by the formula (I) and an alpha-tin-substituted nitrile compound represented by the formula (II) in a solvent to synthesize the alpha-aryl nitrile compound represented by the formula (III). The alpha-aryl nitrile compound is synthesized by the reaction of the aryl sulfoxide and the alpha-tin-substituted nitrile compound under mild conditions. The method has mild reaction conditions, good selectivity, high yield, easy separation of products and simple operation. 本发明公开了种α-芳基腈化合物的制备方法,包括:在酸酐类化合物存在下,结构式(Ⅰ)所示的芳基亚砜与结构式(Ⅱ)所示的α-锡取代的腈类化合物在溶剂中进行反应,合成结构式(Ⅲ)所示的α-芳基腈化合物。该方法通过芳基亚砜与α-锡取代的腈类化合物在温和条件下合成α-芳基腈化合物。该方法反应条件温和、选择性好,收率高、产物易分离、操作简单。