Application of IFNA4 and IFNA10 genes in Crohn's disease

The invention discloses application of IFNA4 and IFNA10 genes in the Crohn's disease, and relates to a method for treating the Crohn's disease with interferon. A drug and/or biological agent for preventing, relieving and/or treating the Crohn's disease comprises IFNA4 and IFNA10 activ...

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Bibliographische Detailangaben
Hauptverfasser: XU HONGZHI, CHENG XIAOSHEN, REN JIANLIN, XIAO CHUANXING, BAYASIGULENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of IFNA4 and IFNA10 genes in the Crohn's disease, and relates to a method for treating the Crohn's disease with interferon. A drug and/or biological agent for preventing, relieving and/or treating the Crohn's disease comprises IFNA4 and IFNA10 activators. Susceptible genes IFNA4 and IFNA10 of a Chinese patient with the Crohn's disease are found through a whole-genome exon high-throughput sequencing technology. The susceptible genes IFNA4 and IFNA10 of the Chinese patient with the Crohn's disease are found. The IFNA4 and IFNA10 genes have the effects of inhibiting development of the Crohn's disease based on IFNA4 and IFNA10, so that a target is provided for developing the drug for the Crohn's disease. The IFNA4 and IFNA10 activators can be used for drugsfor preventing, relieving and/or treating the Crohn's disease. IFNA4与IFNA10基因在克罗恩病中的应用,涉及用干扰素治疗克罗恩病的方法。所述用于预防、缓解和/或治疗克罗恩病药物和/或生物制剂,包括IFNA4和IFNA10激动剂。通过全基因组外显子高通量测序技术发现中国克罗恩病患者易感基因IFNA4和IFNA10。发现中国克罗恩病患者易感基因IFNA4和IFNA10。基于IFNA