Compound ginkgo fiveleaf gynostemma herb trimetazidine injection and preparation method

The invention provides a compound ginkgo fiveleaf gynostemma herb trimetazidine injection and a preparation method. In every 5 ml of injection, 3-9 mg of total flavones, 1.6-6.5 mg of total saponins,1.5-6.5 mg of trimetazidine hydrochloride, 10 mg of sodium hydrogen sulfite, 0.4 ml of absolute ethyl...

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Hauptverfasser: HUANG ZHUOXIAN, XIAO XINRONG, LUO TIAN, MIAO QING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a compound ginkgo fiveleaf gynostemma herb trimetazidine injection and a preparation method. In every 5 ml of injection, 3-9 mg of total flavones, 1.6-6.5 mg of total saponins,1.5-6.5 mg of trimetazidine hydrochloride, 10 mg of sodium hydrogen sulfite, 0.4 ml of absolute ethyl alcohol, 0.6 ml of propylene glycol and 4 ml of water for injection are included, and the pH valueof the injection is 5.2-6.2. The preparation method comprises the specific steps that gingko leaves and fiveleaf gynostemma herb are treated; a crude extracting solution is obtained through ultrasonic concussion; an ultrafiltrate is obtained through ultrafiltration; a purified product containing flavones and saponins is obtained through macroporous resin adsorption and purification; finally, thepurified product powder containing the flavones and the saponins serves as a raw material, the trimetazidine hydrochloride is added, and the compound ginkgo fiveleaf gynostemma herb trimetazidine injection is prepared. 复方银杏绞股蓝曲