QUICK DISSOLVING DIPHENHYDRAMINE ORAL DOSAGE FORM

An oral dosage form to deliver diphenhydramine through the sublingual or buccal mucosa. The oral dosage form can contain diphenhydramine, or a pharmaceutically acceptable salt thereof, a permeabilityenhancer, and a buffering agent. The buffering agent can achieve a pH of about 7.0 to about 8.0. The...

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Bibliographische Detailangaben
Hauptverfasser: SWIGART ERIN NICOLE, TRABOULSI ASHRAF, DANSEREAU RICHARD JOHN, LASTER BRIAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:An oral dosage form to deliver diphenhydramine through the sublingual or buccal mucosa. The oral dosage form can contain diphenhydramine, or a pharmaceutically acceptable salt thereof, a permeabilityenhancer, and a buffering agent. The buffering agent can achieve a pH of about 7.0 to about 8.0. The diphenhydramine can completely dissolve within about 2 minutes. 本发明提供了种通过舌下或颊面黏膜递送苯海拉明的口服剂型。所述口服剂型可包含苯海拉明、或其药学上可接受的盐、渗透增强剂和缓冲剂。所述缓冲剂可达到约7.0至约8.0的pH。苯海拉明可在约2分钟内完全溶解。