Applications of microRNA hsa-mir-593-5p and its analogues, and application in expression of microRNA vector

The invention relates to applications of microRNA hsa-mir-593-5p and its analogues, and an application in the expression of a microRNA vector. The applications of the microRNA hsa-mir-593-5p comprise(1) an application in the preparation of an influenza diagnosis product, (2) an application in the pr...

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Bibliographische Detailangaben
Hauptverfasser: MENG SONGDONG, WANG JING, FANG MIN, WEI SONGTAO, PENG SHANXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to applications of microRNA hsa-mir-593-5p and its analogues, and an application in the expression of a microRNA vector. The applications of the microRNA hsa-mir-593-5p comprise(1) an application in the preparation of an influenza diagnosis product, (2) an application in the preparation of an influenza prevention product, (3) an application in the preparation of an influenzatreatment product, and (4) an application in the preparation of an influenza virus inhibitor. The nucleotide sequence of the hsa-mir-593-5p is represented by SEQ ID NO.1. The expression of the hsa-mir-593-5p is helpful for controlling the influenza viruses in bodies, and the mRNA of the hsa-mir-593-5p is degraded through targeting the PB1 and M fragments of the influenza viruses. 本发明涉及微RNA hsa-mir-593-5p及其类似物的应用,和表达该微RNA载体的应用。本发明提供微RNA hsa-mir-593-5p在如下任项中的应用:(1)制备诊断流感产品中的应用;(2)制备预防流感产品中的应用;(3)制备治疗流感产品中的应用;(4)制备流感病毒抑制剂中的应用;hsa-mir-593-5p的核苷酸序列如SEQ ID NO.1所示。hsa-mir-593-5p的表达有助于机体对于流感病毒的控制,通过靶向流感病毒的PB1和M上的片段,从而降解其mRNA。