ACEIPs (angiotensin converting enzyme inhibitory peptides) extracted from turtle shells and preparation method of ACEIPs

The invention discloses ACEIPs (angiotensin converting enzyme inhibitory peptides) extracted from turtle shells and a preparation method of the ACEIPs. The ACEIPs comprise two active peptides, whereinthe amino acid sequence of one active peptide is Lys-Arg-GluArg, and the amino acid sequence of the...

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Hauptverfasser: LAN XIONGDIAO, ZHOU LIQIN, LIU PENGRU, LIAO PENGYING, SUN LIXIA, LIAO DANKUI, SUN JIANHUA, FENG XUEZHEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses ACEIPs (angiotensin converting enzyme inhibitory peptides) extracted from turtle shells and a preparation method of the ACEIPs. The ACEIPs comprise two active peptides, whereinthe amino acid sequence of one active peptide is Lys-Arg-GluArg, and the amino acid sequence of the other active peptide is Leu-HisMet-Phe-Lys. A reaction feed solution is obtained by extraction withwater from the turtle shells as the raw material, after enzymolysis, microfiltration and ultrafiltration, raw materials of the inhibitory peptides are obtained through separation by a gel chromatographic column and an anion exchange chromatographic column, the raw materials of the inhibitory peptides are subjected to separation and purification with chromatography repeatedly, and the ACEIPs are obtained. The raw material reserves are large, the cost is low, the preparation process is reasonable and high in operability, and the obtained ACEIPs are good in activity. 本发明公开了从鳖甲中提取的血管紧张素转换酶抑制肽及其制备方法,包括两种活性肽,其中种活性肽的氨基酸序列为Ly