Thermo-sensitive gel as well as preparation method and application thereof

The invention provides thermo-sensitive gel as well as a preparation method and application thereof. The thermo-sensitive gel is prepared from the following raw materials in percentage by weight: 18 to 22 percent of thermo-sensitive gel matrixes, 1 percent of permeation enhancer and the balance of water; the thermo-sensitive gel matrixes are poloxamer 407 and poloxamer 188; the permeation enhanceris polyethylene glycol; the thermo-sensitive gel can be used as a carrier of western medicines and traditional Chinese medicines; phase mutation occurs in the drug delivery site and a gel state is formed after the thermo-sensitive gel is smeared on the skin; the transdermal effects of drugs can be effectively improved and the bioavailability of the drugs is improved. 本发明提供了种温敏凝胶剂及其制备方法和应用，所述温敏凝胶剂包括以重量百分比计的以下原料：温敏凝胶基质18％～22％、渗透促进剂1％，其余为水；所述温敏凝胶基质为泊洛沙姆407和泊洛沙姆188；所述渗透促进剂为聚乙二醇。本发明温敏凝胶剂可作为西药及中药载体，将其涂抹于皮肤后，在给药部位发生相突变，形成凝胶态，能有效提高药物经皮渗透效果，提高药物生物利用度。