Compound with 3,2'-pyrrolidine spirooxindole framework and preparation method thereof

The invention discloses a compound with a 3,2'-pyrrolidine spirooxindole framework and a preparation method thereof, and belongs to the field of chemical pharmacy. A chemical structure of the compoundis shown as a formula I: the formula I is shown in the description; in the formula I, R1, R2, R...

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Hauptverfasser: REN HONGXIA, WANG LIXIN, CHEN CHAO, LIAO LIGUO, TANG CHAOZHE, ZOU YING, TIAN FANG, PENG LIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a compound with a 3,2'-pyrrolidine spirooxindole framework and a preparation method thereof, and belongs to the field of chemical pharmacy. A chemical structure of the compoundis shown as a formula I: the formula I is shown in the description; in the formula I, R1, R2, R3 and R4 are respectively selected from one of H, alkyl with the carbon atom number of 1 to 20, halogen,alkoxy, thioether, nitryl, carbonyl, an ester group, amido, hydroxyl, a condensed ring group, a fused ring group and a heteroaromatic ring group; the R1, the R2, the R3 and the R4 are the same or different when existing separately; in the formula I, R5 and R6 are selected from the same group or one of the following different groups: H, carbonyl, alkenyl, alkynyl, a substituent group with the carbon atom number of 1 to 20, the condensed ring group, the fused ring group or the heteroaromatic ring group. The compound disclosed by the invention has the advantages of wide applicability of raw materials, moderate reaction c