Acylated derivative of resiquimod, preparation method and application thereof

The invention relates to an acylated derivative of resiquimod, a preparation method and the application thereof. The general formula of the acylated derivative of resiquimod is as shown in the specification, wherein R1 is selected from one of benzoyl, acetyl, formyl, phenylacetyl and hydrogen; and R2 is selected from one of benzoyl, formyl, hydrogen and acetyl. The acylated derivative of resiquimod provided by the invention has good activity application for oral cancer cells and melanoma cells, and has good clinic application values. The acylated derivative of resiquimod has obvious effects inthe application for curing oral cancer and melanoma. 本发明涉及种瑞喹莫德的酰化衍生物及其制备方法与应用；所述瑞喹莫德的酰化衍生物结构通式如下，其中，R选自苯甲酰基、乙酰基、甲酰基、苯乙酰基或氢中的个；R选自苯甲酰基、甲酰基、氢或乙酰基中的个。本发明提供的瑞喹莫德酰化衍生物对口腔癌细胞、黑色素瘤细胞的具有良好的活性应用，具有良好的临床应用价值。在应用于治疗口腔癌、黑色素瘤中具有显著效果。