PCSK9 iRNA compositions and methods of use thereof

The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the PCSK9 gene, and methods of using such RNAi agents to inhibit expression of PCSK9 and methods of treating subjectshaving a lipid disorder, such as a hyperlipidemia. 本发明涉及靶向PCSK9基因的RNAi剂例如双链RNAi剂，和使用这类RNAi剂来抑制PCSK9表...

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Bibliographische Detailangaben
Hauptverfasser:	MUTHIAH MANOHARAN, WILLIAM QUERBES, MARTIN MAIER, KEVIN FITZGERALD, SATYANARAYANA KUCHIMANCHI, STUART MILSTEIN, ANNA BORODOVSKY, RAJEEV G KALLANTHOTTATHIL, MARIA FRANK-KAMENETSKY, KLAUS CHARISSE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the PCSK9 gene, and methods of using such RNAi agents to inhibit expression of PCSK9 and methods of treating subjectshaving a lipid disorder, such as a hyperlipidemia. 本发明涉及靶向PCSK9基因的RNAi剂例如双链RNAi剂，和使用这类RNAi剂来抑制PCSK9表达的方法以及治疗患有脂质失调例如高脂血症的受试者的方法。