Preparation method of atorvastatin calcium

The invention belongs to the technical field of medicine preparation and particularly relates to a patent application about a novel preparation method of atorvastatin calcium. The method includes steps of preparing intermediates including: 2-methyl-3-carbonyl-methyl pentanoate, 2-methyl-3,5-dicarbonyl-5-anilino-butane, 4-methyl-3-oxo-N-phenyl-2-benzylidene pentanamide, 4-(4-fluorophenyl)-2-(2-methylpropionyl)-4-oxo-N-beta-diphenyl butyrylamide. The preparation method employs cheap and easy-to-obtained raw materials, has simple reactions and operations, and has great industrial application prospect. In conclusion, the preparation method has high reaction efficiency and product yield, is good in repeatability, is suitable for industrial production and has great application value and promotion and application significance. 本发明属于医药制备技术领域，具体涉及种阿托伐他汀钙的新型制备方法专利申请。该方法包括制备2-甲基-3-羰基-戊酸甲酯、2-甲基-3,5-二羰基-5-苯胺基-丁烷、4-甲基-3-氧-N-苯-2-(苯亚甲基)戊酰胺、4-(4-氟苯基)-2-(2-甲基丙酰基)-4-氧代-N-β-二苯基丁酰胺等中间体步骤。本申请所提供的阿托伐他汀钙制备方法，其所采用的原料廉价易得、相关反应操作简单易行，具