Preparation method of 2-methylamino-5-chlorobenzophenone
The invention relates to a preparation method of 2-methylamino-5-chlorobenzophenone. The preparation method comprises the following steps: (1) methylation reaction: performing reaction by using 2-amino-5-chlorobenzophenone as a raw material, using sulfuric acid with certain concentration as a solven...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention relates to a preparation method of 2-methylamino-5-chlorobenzophenone. The preparation method comprises the following steps: (1) methylation reaction: performing reaction by using 2-amino-5-chlorobenzophenone as a raw material, using sulfuric acid with certain concentration as a solvent and using formaldehyde as a methylation reagent to obtain a methylation reaction solution; (2) neutralization: dropwise adding the methylation reaction solution into a mixed solution of ammonia water with certain concentration and an organic solvent, and performing reflux, cooling and filtration or liquid-separation concentration after dropwise addition is carried out so as to obtain a 2-methylamino-5-chlorobenzophenone crude product; (3) purification: purifying the 2-methylamino-5-chlorobenzophenone crude product through an alcohol solvent to obtain a 2-methylamino-5-chlorobenzophenone refined product. The preparation method disclosed by the invention is simple in process, product post-processing is simple and c |
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