Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy
The invention discloses a biological marker used for liver cancer diagnosis and treatment, and more specifically discloses marker LINC01426. It is found for the first time that differential expressionof LINC01426 is related to generation and development of liver cancer; in patients with liver cancer...
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| creator | WANG DONGGUO XING RENWEI MOU YONGHUA |
| description | The invention discloses a biological marker used for liver cancer diagnosis and treatment, and more specifically discloses marker LINC01426. It is found for the first time that differential expressionof LINC01426 is related to generation and development of liver cancer; in patients with liver cancer, expression up-regulation of LINC01426 is detected, it reveal that intervention on LINC01426 geneexpression could be a novel liver cancer treatment method. It is found in verification tests that reduction of LINC01426 expression with inhibitors is capable of reducing propagation and cell formation clone colony number of liver cancer cells obviously.
本发明公开了种用于肝癌诊疗的生物标志物，具体的该标志物为LINC01426。本发明首次发现LINC01426的差异表达与肝癌的发生发展相关，在肝癌患者中，LINC01426的表达上调，提示干预LINC01426基因表达可能成为肝癌治疗的新途径。为了进步验证，通过抑制剂降低LINC01426的表达发现可以显著降低肝癌细胞的增殖和细胞形成克隆集落数。 |
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本发明公开了种用于肝癌诊疗的生物标志物，具体的该标志物为LINC01426。本发明首次发现LINC01426的差异表达与肝癌的发生发展相关，在肝癌患者中，LINC01426的表达上调，提示干预LINC01426基因表达可能成为肝癌治疗的新途径。为了进步验证，通过抑制剂降低LINC01426的表达发现可以显著降低肝癌细胞的增殖和细胞形成克隆集落数。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180615&DB=EPODOC&CC=CN&NR=108165632A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180615&DB=EPODOC&CC=CN&NR=108165632A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG DONGGUO</creatorcontrib><creatorcontrib>XING RENWEI</creatorcontrib><creatorcontrib>MOU YONGHUA</creatorcontrib><title>Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy</title><description>The invention discloses a biological marker used for liver cancer diagnosis and treatment, and more specifically discloses marker LINC01426. It is found for the first time that differential expressionof LINC01426 is related to generation and development of liver cancer; in patients with liver cancer, expression up-regulation of LINC01426 is detected, it reveal that intervention on LINC01426 geneexpression could be a novel liver cancer treatment method. It is found in verification tests that reduction of LINC01426 expression with inhibitors is capable of reducing propagation and cell formation clone colony number of liver cancer cells obviously.
本发明公开了种用于肝癌诊疗的生物标志物，具体的该标志物为LINC01426。本发明首次发现LINC01426的差异表达与肝癌的发生发展相关，在肝癌患者中，LINC01426的表达上调，提示干预LINC01426基因表达可能成为肝癌治疗的新途径。为了进步验证，通过抑制剂降低LINC01426的表达发现可以显著降低肝癌细胞的增殖和细胞形成克隆集落数。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAuDqL-w_kBQtNqcC1BUZRO7uVIrzYQ744kDv69ix_g9Ja3rG6dagweSxDOIBPcr72rzb6xEBhmUiziKcZ3xAQekw8sL4Qx4JMlhwzII5SZEupnXS0mjJk2P1fV9nx6uMuOVAbKip6YyuB6Ux-NPdi26dp_zhe7pTRb</recordid><startdate>20180615</startdate><enddate>20180615</enddate><creator>WANG DONGGUO</creator><creator>XING RENWEI</creator><creator>MOU YONGHUA</creator><scope>EVB</scope></search><sort><creationdate>20180615</creationdate><title>Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy</title><author>WANG DONGGUO ; XING RENWEI ; MOU YONGHUA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108165632A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG DONGGUO</creatorcontrib><creatorcontrib>XING RENWEI</creatorcontrib><creatorcontrib>MOU YONGHUA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG DONGGUO</au><au>XING RENWEI</au><au>MOU YONGHUA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy</title><date>2018-06-15</date><risdate>2018</risdate><abstract>The invention discloses a biological marker used for liver cancer diagnosis and treatment, and more specifically discloses marker LINC01426. It is found for the first time that differential expressionof LINC01426 is related to generation and development of liver cancer; in patients with liver cancer, expression up-regulation of LINC01426 is detected, it reveal that intervention on LINC01426 geneexpression could be a novel liver cancer treatment method. It is found in verification tests that reduction of LINC01426 expression with inhibitors is capable of reducing propagation and cell formation clone colony number of liver cancer cells obviously.
本发明公开了种用于肝癌诊疗的生物标志物，具体的该标志物为LINC01426。本发明首次发现LINC01426的差异表达与肝癌的发生发展相关，在肝癌患者中，LINC01426的表达上调，提示干预LINC01426基因表达可能成为肝癌治疗的新途径。为了进步验证，通过抑制剂降低LINC01426的表达发现可以显著降低肝癌细胞的增殖和细胞形成克隆集落数。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy |
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