Applications of LINC01426 in hepatocellular carcinoma diagnosis and therapy

The invention discloses a biological marker used for liver cancer diagnosis and treatment, and more specifically discloses marker LINC01426. It is found for the first time that differential expressionof LINC01426 is related to generation and development of liver cancer; in patients with liver cancer, expression up-regulation of LINC01426 is detected, it reveal that intervention on LINC01426 geneexpression could be a novel liver cancer treatment method. It is found in verification tests that reduction of LINC01426 expression with inhibitors is capable of reducing propagation and cell formation clone colony number of liver cancer cells obviously. 本发明公开了种用于肝癌诊疗的生物标志物，具体的该标志物为LINC01426。本发明首次发现LINC01426的差异表达与肝癌的发生发展相关，在肝癌患者中，LINC01426的表达上调，提示干预LINC01426基因表达可能成为肝癌治疗的新途径。为了进步验证，通过抑制剂降低LINC01426的表达发现可以显著降低肝癌细胞的增殖和细胞形成克隆集落数。