Selenium-containing photosensitizer as well as preparation method and application thereof

The invention discloses a selenium-containing photosensitizer as well as a preparation method and application thereof. A novel selenium-containing photosensitizer with an anti-tumor angiogenesis effect is synthesized for a first time. The selenium-containing photosensitizer can be applied to treatment on skin scale cancer and is remarkable in effect, the dosage of the selenium-containing photosensitizer is far lower than that of 5-ALA in the market, in addition is free of antibiotics, free of drug resistance and small in side effect, and is safe and non-toxic and economic and practical; in addition, because of the limited light penetration function and other factors, a tumor treatment effect can be achieved even for tumor tissue without light dynamic response through tumor angiogenesis inhibition. 本发明公开了种含硒光敏剂及其制备方法和应用，本发明首次合成了具有抗肿瘤血管生成效果的新型含硒类光敏剂，其用于皮肤鳞癌的治疗中，效果显著，剂量远低于市场上用的5-ALA，且不含抗生素、不产生耐药性、副作用小、安全无毒且经济实用；并且，由于光线的穿透作用有限和些其他因素，即使没有产生光动力反应的肿瘤组织也可以通过抑制肿瘤血管生成来达到治疗肿瘤的效果。