Pyridone amides as modulators of sodium channels
The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of u...
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| creator | BEAR BRIAN RICHARD HADIDA-RUAH SARA SABINA ARUMUGAM VIJAYALAKSMI ANDERSON COREY ASGIAN IULIANA LUCI TERMIN ANDREAS P JOHNSON JAMES PHILIP JR |
| description | The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
本发明涉及作为钠通道调节剂的吡啶酮酰胺，具体地，涉及用作钠通道抑制剂的式(I)和(I')的吡啶酮酰胺化合物或其药学上可接受的盐。本发明还提供包含本发明化合物的药学上可接受的组合物、以及使用该组合物治疗包括疼痛在内的各种疾病的方法。 |
| format | Patent |
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本发明涉及作为钠通道调节剂的吡啶酮酰胺，具体地，涉及用作钠通道抑制剂的式(I)和(I')的吡啶酮酰胺化合物或其药学上可接受的盐。本发明还提供包含本发明化合物的药学上可接受的组合物、以及使用该组合物治疗包括疼痛在内的各种疾病的方法。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180615&DB=EPODOC&CC=CN&NR=108164457A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180615&DB=EPODOC&CC=CN&NR=108164457A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BEAR BRIAN RICHARD</creatorcontrib><creatorcontrib>HADIDA-RUAH SARA SABINA</creatorcontrib><creatorcontrib>ARUMUGAM VIJAYALAKSMI</creatorcontrib><creatorcontrib>ANDERSON COREY</creatorcontrib><creatorcontrib>ASGIAN IULIANA LUCI</creatorcontrib><creatorcontrib>TERMIN ANDREAS P</creatorcontrib><creatorcontrib>JOHNSON JAMES PHILIP JR</creatorcontrib><title>Pyridone amides as modulators of sodium channels</title><description>The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
本发明涉及作为钠通道调节剂的吡啶酮酰胺，具体地，涉及用作钠通道抑制剂的式(I)和(I')的吡啶酮酰胺化合物或其药学上可接受的盐。本发明还提供包含本发明化合物的药学上可接受的组合物、以及使用该组合物治疗包括疼痛在内的各种疾病的方法。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAIqCzKTMnPS1VIzM1MSS1WSCxWyM1PKc1JLMkvKlbIT1Mozk_JLM1VSM5IzMtLzSnmYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GBhaGZiYmpuaOxsSoAQBrwyts</recordid><startdate>20180615</startdate><enddate>20180615</enddate><creator>BEAR BRIAN RICHARD</creator><creator>HADIDA-RUAH SARA SABINA</creator><creator>ARUMUGAM VIJAYALAKSMI</creator><creator>ANDERSON COREY</creator><creator>ASGIAN IULIANA LUCI</creator><creator>TERMIN ANDREAS P</creator><creator>JOHNSON JAMES PHILIP JR</creator><scope>EVB</scope></search><sort><creationdate>20180615</creationdate><title>Pyridone amides as modulators of sodium channels</title><author>BEAR BRIAN RICHARD ; HADIDA-RUAH SARA SABINA ; ARUMUGAM VIJAYALAKSMI ; ANDERSON COREY ; ASGIAN IULIANA LUCI ; TERMIN ANDREAS P ; JOHNSON JAMES PHILIP JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108164457A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BEAR BRIAN RICHARD</creatorcontrib><creatorcontrib>HADIDA-RUAH SARA SABINA</creatorcontrib><creatorcontrib>ARUMUGAM VIJAYALAKSMI</creatorcontrib><creatorcontrib>ANDERSON COREY</creatorcontrib><creatorcontrib>ASGIAN IULIANA LUCI</creatorcontrib><creatorcontrib>TERMIN ANDREAS P</creatorcontrib><creatorcontrib>JOHNSON JAMES PHILIP JR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BEAR BRIAN RICHARD</au><au>HADIDA-RUAH SARA SABINA</au><au>ARUMUGAM VIJAYALAKSMI</au><au>ANDERSON COREY</au><au>ASGIAN IULIANA LUCI</au><au>TERMIN ANDREAS P</au><au>JOHNSON JAMES PHILIP JR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pyridone amides as modulators of sodium channels</title><date>2018-06-15</date><risdate>2018</risdate><abstract>The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
本发明涉及作为钠通道调节剂的吡啶酮酰胺，具体地，涉及用作钠通道抑制剂的式(I)和(I')的吡啶酮酰胺化合物或其药学上可接受的盐。本发明还提供包含本发明化合物的药学上可接受的组合物、以及使用该组合物治疗包括疼痛在内的各种疾病的方法。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyridone amides as modulators of sodium channels |
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