Pyridone amides as modulators of sodium channels

The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of u...

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Bibliographische Detailangaben
Hauptverfasser: BEAR BRIAN RICHARD, HADIDA-RUAH SARA SABINA, ARUMUGAM VIJAYALAKSMI, ANDERSON COREY, ASGIAN IULIANA LUCI, TERMIN ANDREAS P, JOHNSON JAMES PHILIP JR
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. 本发明涉及作为钠通道调节剂的吡啶酮酰胺,具体地,涉及用作钠通道抑制剂的式(I)和(I')的吡啶酮酰胺化合物或其药学上可接受的盐。本发明还提供包含本发明化合物的药学上可接受的组合物、以及使用该组合物治疗包括疼痛在内的各种疾病的方法。