Fluorescence specific nanometer iron oxide hybrid dispersion liquid for cancer metastatic lymph node tracing as well as preparation method and purpose of fluorescence specific nanometer iron oxide hybrid dispersion liquid

The invention relates to the field of medical preparations, in particular to fluorescence specific nanometer iron oxide hybrid dispersion liquid for cancer metastatic lymph node tracing as well as a preparation method and a purpose of the fluorescence specific nanometer iron oxide hybrid dispersion...

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Hauptverfasser: LI GUOXIN, ZHOU HAIPENG, DENG HAIJUN, WANG YANAN, FU CHAOPING, ZHANG LIMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of medical preparations, in particular to fluorescence specific nanometer iron oxide hybrid dispersion liquid for cancer metastatic lymph node tracing as well as a preparation method and a purpose of the fluorescence specific nanometer iron oxide hybrid dispersion liquid. The fluorescence specific nanometer iron oxide hybrid dispersion liquid for cancer metastatic lymph node tracing comprises a dextran derivative, iron oxide particles and water; the dextran derivative is combined with the iron oxide particles to form a nanometer iron oxide hybrid which is uniformly dispersed in the water and is prepared from the dextran derivative and ferric salt through a coprecipitation method; and the dextran derivative is prepared from 5-aminolevulinic acid and oxidized dextran through Schiff base reaction. The prepared fluorescence specific nanometer iron oxide hybrid dispersion liquid is hopeful to be applied to evaluation of gastrointestinal cancer metastatic lymph nodes and can be co