Synthesis method of 2-hydroxyl-3-(3,4-dimethoxy phenyl)propionic acid

The invention belongs to the field of medicine preparation and specifically relates to a synthesis method of 2-hydroxyl-3-(3,4-dimethoxy phenyl)propionic acid. The synthesis method of 2-hydroxyl-3-(3,4-dimethoxy phenyl)propionic acid comprises the following steps: with veratral hydantoin as a raw material and alkali as a catalyst, closing and pressurizing for reacting; after the reaction is completed, performing vacuum concentration, neutralizing, cooling, filtering and washing to obtain 2-hydroxyl-3-(3,4-dimethoxy phenyl)propionic acid. The synthesis method provided by the invention has the advantages of easily available raw material, low toxicity, few wastes, easiness in treatment, promotion of environmental protection, high-purity target product and satisfaction of the needs for impurity research. 本发明属于药物制备领域，具体涉及种2-羟基-3-(3,4-二甲氧基苯基)丙酸的合成方法。所述的2-羟基-3-(3,4-二甲氧基苯基)丙酸的合成方法，以亚藜芦基乙内酰脲为原料，以碱为催化剂，密闭加压反应，反应完毕，减压浓缩，中和，降温，过滤、水洗，得2-羟基-3-(3,4-二甲氧基苯基)丙酸。本发明所述的合成方法，所用原料易得，毒性小，产生废物少，易于处理，利于环保，可得到纯度高的目标产物，满足对杂质研究的需求。