Preparation method of syrigopicroside solid lipid nanoparticles

The invention provides a preparation method of syrigopicroside solid lipid nanoparticles and relates to a preparation method of a medicine, aiming at solving the problems that the liver targeting effect of a traditional Chinese medicine effective monomer component hepatitis B virus resisting medicine, i.e., syrigopicroside, in liver cells is poor, the bioavailability is low and the half-life period is short. According to the preparation method provided by the invention, monoglyceride, lecithin, the syrigopicroside and absolute ethyl alcohol are mixed to form an oil phase and an F68 solution isused as a water phase; after the oil phase and the water phase are stirred, mixed and concentrated, a diluting phase is added and is continually stirred to obtain the product. The syrigopicroside solid lipid nanoparticles prepared by the preparation method can be used for improving the targeting performance of the syrigopicroside, prolonging the action time of the medicine on livers and reducingthe toxic and side effects