Oxoindole spiral tetrahydrofuran framework and its crystal and preparation method

The invention discloses an oxoindole spiral tetrahydrofuran framework and its preparation method. The structural formula is shown as Formula I. The invention further discloses a crystal form of the compound shown in Formula I; the crystal form is a monoclinic system, the cell parameter alpha is equal to 90 degrees, beta is equal to 94.278(3) degrees, and gamma is equal to 90 degrees; the space group is P21, Z=2; the cell volume is shown as specification. The invention further discloses a preparation method of the crystal form, and also discloses an application of the compound, or its crystal form, or its solvent compound, or pharmaceutically acceptable salts in preparation of anti-cancer drugs. 本发明公开了种氧化吲哚螺四氢呋喃骨架物及其制备方法，它的结构式如式Ⅰ所示，本发明还公开了式Ⅰ所示化合物的晶型：该晶型为单斜晶系，晶胞参数为α＝90°，β＝94.278(3)°，γ＝90°，空间群为P2，Z＝2，晶胞体积为。本发明还公开了制备这种晶型的方法，并公开了本发明化合物、或其晶型、或其溶剂合物、或其药学上可接受的盐在制备抗肿瘤药物中的用途。