Lactobillus for use as probiotic and blood cell populations used for evaluating immune response to agents, e.g. probiotics

A probiotic formulation, comprising Lactobacillus plantarum TIFN 101 deposited under number CBS 138100 or a bacterial strain comprising a polynucleotide that has at least 85% sequence identity with apolynucleotide from L.plantarum, the use of the formulation in the therapy and the probiotic bacteria...

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Bibliographische Detailangaben
Hauptverfasser:	MUJAGIC ZLATAN, FAAS MARIA MARGARETHA, DE VOS PAULUS, TROOST FREDERIK JAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	A probiotic formulation, comprising Lactobacillus plantarum TIFN 101 deposited under number CBS 138100 or a bacterial strain comprising a polynucleotide that has at least 85% sequence identity with apolynucleotide from L.plantarum, the use of the formulation in the therapy and the probiotic bacterial strain itself. A method for the detection of a response, preferably an immune response, to an agent comprising: a) stimulating peripheral blood mononuclear cells (PBMC) with at least one antigen, b) identifying a sub-population of PBMC, c) comparing the sub-population of PBMC to a reference sample which has not been stimulated with the at least one antigen of (a). The sub-population of PBMC may be CD3+/CD4+ (Thelper cells). 益生菌制剂，其包含保藏为CBS138100的Lactobacillus plantarum TIFN 101或含有与来自L.plantarum的多核苷酸具有至少85％序列同性的多核苷酸的细菌菌株，以及所述制剂在疗法中的用途和所述益生菌菌株本身。检测对试剂的应答、优选地免疫应答的方法，所述方法包括：a)利用至少种抗原刺激外周血单核细胞(PBMC)；b)鉴定PBMC的亚群；c)将所述PBMC的亚群与未用(a)的至少种抗原刺激的参照样品进行比较。PBMC亚群可以是CD3+/CD4+(T辅助细胞)。