Method of preparing poly-substituted dialkene from crotonic acid derivatives

The invention discloses a method of preparing poly-substituted dialkene from crotonic acid derivatives. The invention relates to a preparation method of poly-substituted 1,3-dialkene. The preparationmethod comprises following steps: dissolving a raw material I (aldehyde/ketone/formate), a raw material II (crotonic acid derivatives), an alkali, and a Lewis acid into an organic solvent; and carrying out reactions for 1 to 8 hours under stirring at a proper temperature to obtain the target product III (poly-substituted 1,3-dialkene). The method has the advantages that the conditions are mild, the inert gas protection is not needed, the operation is simple and convenient, the atom utilization rate is high, and the substrate application range is wide, and the method is suitable for industrialamplification and has a good industrialization prospect. 本发明公开了种由巴豆酸衍生物制备多取代二烯烃的方法。本发明涉及种多取代1,3-二烯的制备方法。其主要步骤是：在有机溶剂中依次溶入原料I（醛/酮/甲酸酯）,原料II（巴豆酸衍生物）,碱和路易斯酸，适当温度下搅拌反应1~8小时，得到目标产物III（多取代1,3-二烯）。该方法条件温和，无需惰性气体保护，操作简便，原子利用率高，底物应用范围广