Tetrahydropyrane[2,3-b]indole framework material as well as crystal, preparation method and application thereof

The invention discloses a tetrahydropyrane[2,3-b]indole framework material as well as a crystal, a preparation method and an application thereof. The framework material has the structural formula shown in formula I, the crystal form of the compound is a monoclinic system, the crystal cell parameters...

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Hauptverfasser: YANG KAICHUAN, LENG HAIJUN, ZHU HONGPING, ZHANG XIANG, LI QINGZHU, ZHANG YING, LIU YUE, DAI QINGSONG, SHEN XUDONG, LI JUNLONG, ZENG RONG, LAI HANYU, LIU YU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a tetrahydropyrane[2,3-b]indole framework material as well as a crystal, a preparation method and an application thereof. The framework material has the structural formula shown in formula I, the crystal form of the compound is a monoclinic system, the crystal cell parameters are shown as follows: a is 9.5716 (4) angstrom, b is 9.7736(3) angstrom, c is 9.6582(4) angstrom, alpha is 90 degrees, beta is 100.380(4) degrees, gamma is 90 degrees, the space group is P21, Z is 2, and the crystal cell volume is 888.74(6) angstrom . The invention also discloses the preparationmethod of the crystal form as well as an application of the compound or the crystal form, a solvate or pharmaceutically acceptable salt thereof in preparing antibacterial medicines. The yield and purity of the crystal form are high, the crystal form of the high-purity compound can be obtained easily, the operation is simple, the cost is low, and the quality control of the compound shown in formulaI is better facilitated. Me