Preparation method of catheter surface antibacterial coating

The invention relates to the field of catheters, and particularly relates to a preparation method of a catheter surface antibacterial coating. The preparation method comprises the following steps: (1)pretreating the surface of the catheter; (2) triggering acrylic acid polymerization on the surface of the catheter; and (3) constructing an antibacterial surface through layer-by-layer self assembling of hyaluronic acid and polyimidazole salt. Multiple layers of polymer ion films are prepared on the surface of the catheter by combining surface radical polymerization triggering and layer-by-layerself-assembling methods, so that the surface of the catheter has excellent antibacterial property and biocompatibility, and has the characteristics of simplicity in operation, controllable surface structure, durable antibacterial ability and the like. 本发明涉及导尿管领域，具体为种导尿管表面抗菌涂层制备方法。该制备方法包括如下步骤：(1)导尿管表面的预处理；(2)导尿管表面引发丙烯酸聚合；(3)利用透明质酸和聚咪唑盐层层自组装构筑抗菌表面。本发明由表面自由基引发聚合和层层自组装方法相结合，在导尿管表面制备多层聚合物离子膜，进而导尿管表面具有优良的抗菌性能和生物相容性，具有操作简单、表面结构可控