Application of salvianolic acid B and analogues of salvianolic acid B in preparing anti-HPV-viral-infection medicine

The invention discloses application and salvianolic acid B and analogues of the salvianolic acid B in preparing anti-HPV-viral-infection medicine, and belongs to the field of biomedicine. The inventordiscovers that the salvianolic acid B and the analogues, such as myricetin and dihydromyricetin, of...

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Hauptverfasser: WEN JIAYONG, LAI FANGYUAN, DING YONGZHEN, LI LIN, LIU SHUWEN, YIN SHUWEN, LIANG TAIZHEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application and salvianolic acid B and analogues of the salvianolic acid B in preparing anti-HPV-viral-infection medicine, and belongs to the field of biomedicine. The inventordiscovers that the salvianolic acid B and the analogues, such as myricetin and dihydromyricetin, of the salvianolic acid B for the first time through researches, the salvianolic acid b and the analogues of the salvianolic acid B have good anti-HPV-viral-infection activity and can effectively block adhering of HPV viruses to target cells, and then HPV viral infection is inhibited. Experiments prove that the salvianolic acid B and capsid protein of the viruses can be directly bound, and adhesion of antagonism viruses to the target cells achieves an anti-virus effect. The salvianolic acid B actsin the early stage that the viruses enter the cells, and can also act in the middle stage and the later stage that the viruses enter the cells. The effects are better than medicine only acting on theearly stage that the virus