GITRL FUSION PROTEINS AND USES THEREOF

The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits canself-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer. 本披露提供包括IgG Fc结构域、三聚结构域、和GITR配体的受体结合结构域的GITRL融合多肽亚基，其中这些融合多肽亚基可自组装成六聚体蛋白。还提供制造融合多肽亚基和六聚体蛋白的方法，以及例如用于治疗癌症的方法。