Antimicrobial peptide FR-31 and application thereof

The solution discloses a short-chain polypeptide in the biotechnology field, antimicrobial peptide FR-31, the amino acid sequence of which is Phe-Arg-Ala-Ser-Gly-Gln-IIe-Thr-IIe-Thr-Val-Lys-Pro-Arg-Phe-Arg-Arg-IIe-Lys-Arg-Leu-Phe-Arg-Gly-Phe-Arg-Gly-Arg-Gln-Val-Leu. The antimicrobial peptide product...

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Bibliographische Detailangaben
Hauptverfasser:	LI JUN, XIA QIANG, LIU ZHENYONG, GOU HONGWEI, YANG CHUANHUI, YANG YUFENG, PENG LIPING, LU RONGRUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY FODDER FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The solution discloses a short-chain polypeptide in the biotechnology field, antimicrobial peptide FR-31, the amino acid sequence of which is Phe-Arg-Ala-Ser-Gly-Gln-IIe-Thr-IIe-Thr-Val-Lys-Pro-Arg-Phe-Arg-Arg-IIe-Lys-Arg-Leu-Phe-Arg-Gly-Phe-Arg-Gly-Arg-Gln-Val-Leu. The antimicrobial peptide product disclosed by the invention does not cause hemolysis, the antimicrobial spectrum is broad, the antimicrobial peptide FR-31 has an excellent antimicrobial effect on both Gram-positive bacteria and Gram-negative bacteria as well as excellent inhibition effect on fungi. Therefore, the antimicrobial peptide FR-31 disclosed by the invention can be applied well in the preparation of medicines for resisting the infection of the Gram-positive bacteria or/and the Gram-negative bacteria or/and fungal diseases. 本方案公开了生物技术领域的种短肽，抗菌肽FR-31，其氨基酸序列为：Phe-Arg-Ala-Ser-Gly-Gln-IIe-Thr-IIe-Thr-Val-Lys-Pro-Arg-Phe-Arg-Arg-IIe-Lys-Arg-Leu-Phe-Arg-Gly-Phe-Arg-Gly-Arg-Gln-Val-Leu。本发明抗菌肽产品不产生溶血性，抗菌谱广，对革兰氏阳性菌和革兰氏阴性菌都具有极好的抗菌作用，对真菌也有极好的抑菌效果。所以