Substituted olefin compound, and preparation method and application thereof

The invention provides a substituted olefin compound, and a preparation method and application thereof. Specifically, the application provides a substituted olefin compound, a stereoisomer, prodrug, solvate, and pharmaceutically acceptable salt or ester of the substituted olefin compound, a preparat...

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Hauptverfasser: DU JING, WANG JINGYI, ZENG HONG, WANG RUNJIANG, LIU GANG, GE YONG, WANG LICHUN, ZHANG YUANYUAN, SONG HONGMEI, DONG ZHENWEN, YU HUA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a substituted olefin compound, and a preparation method and application thereof. Specifically, the application provides a substituted olefin compound, a stereoisomer, prodrug, solvate, and pharmaceutically acceptable salt or ester of the substituted olefin compound, a preparation method of the substituted olefin compound, and an application in preparing medicines for treating diseases relative to an excessive activity of estrogen receptors (such as ERalpha). 本申请提供种取代的烯烃类化合物及其制备方法和用途。具体地,本申请提供种取代的烯烃类化合物、其立体异构体、前药、溶剂合物、药学上可接受的盐或酯,及其制备方法和在制备治疗与雌激素受体(例如ERα)过度活性相关的疾病的药物中的用途。