Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration

The present disclosure relates to ejector mechanisms and devices for generating a directed stream of droplets, as well as improved methods for delivering an ejected stream of droplets to a target. Thedevice and methods may be useful for the delivery of fluid for ophthalmic, topical, oral, nasal, or pulmonary use, more particularly, for use in the delivery of ophthalmic fluid to the eye. Certain aspects of the disclosure relate to devices and methods for the delivery of a therapeutically effective low dosage volume medicament composition to a target, e.g., by controlling charge, droplet size and/or droplet deposit parameters of the medicament composition. 本公开内容涉及喷射器机械装置和设备，其用于产生定向微滴流，以及改善的用于递送喷射的微滴流至靶标的方法。设备和方法可以适用于流体的递送，所流体用于眼的，局部的，口服，鼻部，或肺部使用，更具体地，用于在将眼的流体递送至眼中的使用。公开内容的某些方面涉及设备和方法，所述设备和方法用于将治疗有效低剂量体积药物组合物递送至靶标，例如，通过控制所述药物组合物的荷电，微滴尺寸和/或微滴沉积参数。