Preparation method for antitumor active compound dolastatin 10 Dil fragment

The invention belongs to the field of chemical synthesis, and relates to a preparation method for an antitumor active compound dolastatin 10 Dil fragment. The method for preparing the dolastatin 10 Dil fragment comprises the steps of performing conversion from an intermediate 1 to Dil, and synthesizing the compound according to steps 1-6. The method provided by the invention has the advantages ofa simple route, simple operation and a higher yield, and reagents used in the method are all common reagents; and in particular, the preparation costs of the technical route of the preparation methodare obviously reduced, the stereoselectivity is high, and the reaction conditions are mild. 本发明属于化学合成领域，涉及种抗肿瘤活性化合物海兔毒素Dil片段制备方法。本发明所述制备海兔毒素Dil片段的方法，包括从中间体1-Dil转化，按步骤1-6合成化合物：本方法路线简洁，操作简单，收率较高，所用的试剂均为常用试剂，尤其，本制备方法的技术路线制备的成本明显降低，立体选择性高，反应条件温和。