Synthesis method of Osimertinib

The invention discloses a synthesis method of Osimertinib. The method comprises the following steps that (1) 4-fluoro-2-methoxyl-5-nitroaniline is subjected to formylation to obtain N-(4-fluoro-2-methoxyl-5-nitrophenyl) methanamide; (2) N-methylindole is subjected to acylation reaction to prepare 3-(1-methyl-1H-indole-3-yl)prop-2-en-1-one; (3) products generated in the former two-step reactions are subjected to one-step cyclization to obtain 2-(4-fluoro-2- methoxyl-5- nitroanilino)-4-(1-methyl-1H-indole-3-yl) pyrimidine; (4) the product generated in the step (3) is sequentially subjected to nucleophilic substitution reaction, reduction reaction and condensation amidation reaction to obtain the Osimertinib. The method provided by the invention has the advantages that the raw materials can be easily obtained; the steps are simple; the yield is high; the reaction conditions are mild; the synthesis method is suitable for industrial production. 本发明公开了种奥斯替尼的合成方法，该方法包括如下步骤：(1)将4-氟-2-甲氧基-5-硝基苯胺经过甲酰化得到N-(4-氟-2-甲氧基-5-硝