ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTI-CD123-ANTIBODIES

The invention relates to novel antibody drug conjugates (ADCs), active metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for the treatment and/or prevention of diseases, and to the use of said ADCs for the production of medicaments for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases, such as cancer diseases.Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures. 本发明涉及新的抗体药物缀合物(ADC)、所述ADC的活性代谢物、涉及制备所述ADC的方法、涉及所述ADC用于治疗和/或预防疾病的用途，以及涉及所述ADC用于产生用于治疗和/或预防疾病(特别是过度增殖性疾病和/或血管生成性疾病，例如癌症疾病)的药剂的用途。所述治疗可作为单疗法起作用或与其他药物或其他治疗措施结合。