Bispecific antibody FITCCD3 as well as preparation method and application thereof

The invention discloses a bispecific antibody FITC*CD3 as well as a preparation method and an application thereof and belongs to the fields of biological pharmacy and immunology. An immune cell antigen targeted by the bispecific antibody FITC*CD3 is CD3, and a targeted target antigen is fluorescein...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GUO CHANGYING, KANG MENGSHI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a bispecific antibody FITC*CD3 as well as a preparation method and an application thereof and belongs to the fields of biological pharmacy and immunology. An immune cell antigen targeted by the bispecific antibody FITC*CD3 is CD3, and a targeted target antigen is fluorescein FITC. After the bispecific antibody FITC*CD3 is combined with an FITC modified antibody, T-lymphocytes can be targeted to tumor cells to kill the tumor cells. Compared with independent use of the antibody, the bispecific antibody can enhance pharmaceutical effect and promote immunoreaction of an organism for the tumor cells. The bispecific antibody FITC*CD3 is combined with different FITC modified antibodies, so that the obtained bispecific antibody can target multiple kinds of tumor cells. Theantibody is a biomacromolecular treatment drug prepared with a cell engineering technology and a gene engineering technology and has the advantages of being high in specificity, uniform in property, capable of realizing direc