Crystalline forms of bilastine and preparation methods thereof

The invention relates to novel alpha and [eta] crystalline forms of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl)ethyl]-[alpha],[alpha]-dimethyl-benzeneacetic acid (bilastine). The invention also relates to methods for the preparation of these crystalline forms of bilastine, pharmaceutical compositions containing same and the use thereof in the treatment of histamine-mediated disease processes and allergic reactions. 本发明涉及4-[2-[4-[1-(2-乙氧基乙基)-1H-苯并咪唑-2-基]-1-哌啶基)乙基]-α,α-二甲基-苯乙酸(比拉斯汀)的新α和η晶型。本发明还涉及其制备方法，含有其的药物组合物，以及其在治疗组胺介导的疾病过程和过敏反应中的用途。