PH-dependent vaginal compositions and methods of treatment of vaginal disorders

The present invention provides a pH dependent vaginal composition delivering a therapeutically effective amount of at least one active essentially at a pH above 4.5. The composition provides a diagnostic visual pH indication of the presence of vulvovaginitis at pH above 4.5. In the absence of such indication, the treatment may be discontinued. Another visual signal is the retrieval of the unchanged composition, which also points to a normal pH at or below 4.5 and absence of vulvovaginitis. 本发明提供种pH依赖型阴道组合物，其大体在pH高于4.5的情况下递送治疗有效量的至少种活性成分。该组合物提供种诊断性的可视pH指示，其在pH高于4.5的情况下指示患有外阴阴道炎。在没有这种指示的情况下，可以中止治疗。另种可视信号是取回未改变的组合物，这还指示了4.5或其以下的正常pH以及无外阴阴道炎。