Sericin hydrogel as well as preparation method and application thereof

The invention discloses sericin hydrogel as well as a preparation method and application thereof. According to the method, the sericin hydrogel having new characteristics is obtained by simultaneouslycross-linking a sericin aqueous solution, extracted from silkworm cocoon of a specific bombyx mori silk fibroin deletion mutant species, with two cross-linking agents. The sericin hydrogel prepared by the method provided by the invention has new fluorescence characteristics, i.e., superior green and red fluorescence characteristics, has a microstructure different from the traditional hydrogel, and has a compound micropore structure of two types of micropores; furthermore, the sericin hydrogel has the characteristics of deformation memory, injectability and in-situ gelation; the sericin hydrogel has good biocompatibility and cell adhesion, and has a good controlled release effect on drugs; the sericin hydrogels and a freeze-dried three-dimensional porous sericin biological scaffold thereofcan serve as extracellula