(S)-tetrahydro Angustine derivative, and preparation method and use thereof

The invention provides an (S)-tetrahydro Anthusine derivative and a pharmaceutically acceptable salt thereof. The (S)-tetrahydro Anthusine derivative is obtained through a series of structure modifications of strictosidine used as a starting material, and the strictosidine is synthesized by through catalyzing tryptamine and ring-split strychnine by strictosidine synthase. Monochiral polycyclic mother nucleus compounds which are difficult to synthesize through conventional medicinal chemistry are synthesized in the invention, and the compounds have outstanding in vitro topoisomerase I inhibition activity and in vitro anti-HepG2 tumor activity, and can be used in the preparation of topoisomerase I inhibitor anticancer drugs. The general structure of the (S)-tetrahydro Anthusine derivative isrepresented by formula (I) shown in the description. 本发明提供种（S）-四氢Angustine衍生物及其可药用的盐，利用异胡豆苷合成酶催化色胺和裂环马钱子碱合成的异胡豆苷为起始物，通过系列结构修饰得到。本发明合成了传统药物化学难以合成的类单手性的多环母核化合物，此类化合物具有突出的体外拓扑异构酶I抑制活性与体外抗HepG2肿瘤活性，可在制备拓扑异构酶I抑制剂类抗肿瘤药物中进行应用。具有以下式