Synthetic method for beta-amino acids and beta-amino acids synthesized by adopting method

The invention relates to a novel synthetic method for beta-amino acids and the beta-amino acids synthesized by adopting the method. The method comprises the following steps: an amide and an azo diacidester are taken as raw materials, an intermediate compound I is synthesized through direct carbon-hy...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG SHUYU, BAI HEYUAN, DING TONGMEI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a novel synthetic method for beta-amino acids and the beta-amino acids synthesized by adopting the method. The method comprises the following steps: an amide and an azo diacidester are taken as raw materials, an intermediate compound I is synthesized through direct carbon-hydrogen bond amination under the action of a catalyst, the intermediate compound I reacts with methyl bromoacetate to synthesize an intermediate compound II, an amide protecting group is removed under acidic conditions, and therefore the beta-amino acid is obtained; and the chemical structural formula of the beta-amino acid obtained by synthesis is shown in the description, wherein in a formula, R1 and R2 are separately one selected from the group consisting of hydrogen, alkyl, branched alkyl, cycloalkyl, aryl, aryl with various substituents, a heterocyclic group and a heterocyclic group with various substituents; and R3 is an ester group. Compared with the prior art, the method provided bythe invention synthesizes