Preparation methods of niraparib and intermediate of niraparib as well as intermediate compound

The invention discloses a preparation method of an intermediate of niraparib. The intermediate is as shown in the following formula. The preparation method comprises the following steps of using (S)-oxazolidone and p-bromophenylacetic acid as initial raw materials, and carrying out amide condensation, Michael addition, the reduction of ester and amide, the synthesis of sulfonyl ester, ammonification ring formation and a reaction of salt formation with an organic acid, so as to obtain the intermediate. The invention also discloses a preparation method of the niraparib and an intermediate compound of the niraparib. The preparation methods provided by the invention are low in cost and are suitable for industrialized production; raw materials are easily obtained and the yield is higher. The formula structure is shown in the description. 本发明公开了种尼拉帕尼的中间体的制备方法，如下式所示，其包含下列步骤：以(S)-恶唑烷酮与对溴苯乙酸为起始原料，进行酰胺缩合，迈克尔加成，脂和酰胺的还原，磺酰脂的合成，氨化成环，与有机酸成盐的反应，即可。本发明还公开了尼拉帕尼的制备方法及其中间体化合物。本发明的制备方法成本低，原料易得，产率较高，适于工业化生产。