25-hydroxy-16-one-26.28-bishomo-cholecalciferols

The invention relates to a compound of the formula wherein A is Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH2 or R is hydrogen or fluoro and R1 is =CH2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatm...

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Bibliographische Detailangaben
Hauptverfasser:	M.R. USKOKOVIC, J.A. IACOBELLI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a compound of the formula wherein A is Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH2 or R is hydrogen or fluoro and R1 is =CH2. Compounds of formula I stimulate HL-60 cell differentiation. Accordingly, the compounds of formula I are useful as agents for the treatment of neoplastic diseases, such as leukemia.