Method for synthesis of 2-(1-chloro-cyclopropane-1-yl)-3-chloro-1-(2-chloro-phenyl)-2-propanol

The invention discloses a method for one-step synthesis of 2-(1-chloro-cyclopropane-1-yl)-3-chloro-1-(2-chloro-phenyl)-2-propanol. The method comprises that magnesium chips are added into an anhydroussolvent system in the nitrogen protective atmosphere, an initiator and a small amount of 2-chlorobenzyl chloride are added into the system to initiate a Grignard reaction, 2-chlorobenzyl chloride and2-chloro-1-(1-chloro-cyclopropyl)-ethanone are added into the reaction product drop by drop so that the system simultaneously undergoes a Grignard reaction and a nucleophilic addition reaction, and the reaction product is subjected to acidification hydrolysis to produce a desired product 2-(1-chloro-cyclopropane-1-yl)-3-chloro-1-(2-chloro-phenyl)-2-propanol. The method prevents the high concentration accumulation of Grignard reagent in the reaction process, inhibits the self-coupling Wurtz side reaction of o-chlorobenzyl chloride during Grignard reaction and improves the yield and content ofthe desired product. 本发明公开了